When would you suggest i start handling my ball python?

First of all, I would wait to handle it for about a week. Let it get used to its surroundings. As for holding a snake 48hrs after eating, it's recommended that you don't hold it because it could regurgitate. When changing from live to frozen/thawed, ball pythons could be a bit picky. I would recommend getting large feeding tongs and move the mouse a bit if the snake hasn't eaten it after about half an hour. Feeding after 15 days is correct, but always make sure that the feeder is a good size (same width as the thickest part of the snake in ball pythons). *reads over again* I think I answered all of your questions :)